AI-assisted analysis helps find new targets for CAR-T cell therapy against acute myeloid leukemia
Unlike other forms of blood cancer, acute myeloid leukemia (AML) cannot currently be treated with CAR-T cell immunotherapy. The reason is that specific molecular targets with which certain immune cells could specifically target AML...
Novel class of encrypted peptides offers hope against drug-resistant bacteria
In a significant advance against the growing threat of antibiotic-resistant bacteria, researchers have identified a novel class of antimicrobial agents known as encrypted peptides, which may expand the immune system's arsenal of tools to...
Viral host jumps: Humans to animals transmission more common than previously thought
In a recent study published in Nature Ecology & Evolution, researchers harnessed publicly available viral genomic data, using a comprehensive suite of network and phylogenetic analyses to investigate the evolutionary mechanisms underpinning recent viral...
First COVID-19 vaccine found to be safe, able to generate rapid immune response in...
Reviewed by Emily Henderson, B.Sc.May 22 2020
The first COVID-19 vaccine to reach phase 1 clinical trial has been found to be safe, well-tolerated, and able to generate an immune response against SARS-CoV-2 in humans,...
The age of the Earth’s inner core revised
Credit: NASA/ Gary A.Glatzmaier
By creating conditions akin to the center of the Earth inside a laboratory chamber, researchers have improved the estimate of the age of...
Depleting SIRPα-deficient in macrophages activate tumor antigen-specific cytotoxic T cells
In a study that will be published in Nature Communications on May 28, 2021, a research team led by Dr. Yuan Liu from Georgia State University reports that intratumoral SIRPα-deficient macrophages activate tumor antigen-specific...
Intestinal Stretch Tells Brain to Switch Off Appetite
When we say we feel “full” after eating a meal, we probably think that the feeling of satiety results from having a full stomach. The results of studies by researchers at the University of...
UofL researchers are unmasking an old foe’s tricks to thwart new diseases
When the body encounters bacteria, viruses or harmful substances, its innate immune cells, neutrophils, assemble at the site to combat the invader.
Credit: UofL photo.
When the body encounters bacteria, viruses or harmful substances, its innate...
Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses
In a recent study published in Nature Biomedical Engineering, researchers used an interdisciplinary approach incorporating phylogenetics, 3D protein modeling, and plasmid design to identify and computationally design an antigen representing the core of most...
COVID-19 lung injury is not like high altitude pulmonary edema
Reviewed by Emily Henderson, B.Sc.Apr 20 2020
A group of researchers with experience in treating high altitude pulmonary edema (HAPE) have written to correct the misconception in medical social media forums and elsewhere that the...
