Cellevate has reported the successful scaleup of its Cellevat3d® nanofiber microcarriers funded by Vinnova/STUNS Life Science. The study was performed at Testa Center in Uppsala, Sweden, in the 10-L Xcellerex XDR-10 single-use stirred tank bioreactor (Cytiva).
![The Cellevat3d nanofiber microcarrier study was performed at Testa Center in Uppsala, Sweden, in the 10-liter Xcellerex XDR-10 single-use stirred tank bioreactor (Cytiva). [Cellevate]](https://www.genengnews.com/wp-content/uploads/2024/10/Cellevate-at-Testa-Center_Oct24_4-300x225.jpg)
The nanofiber-based Cellevat3d microcarriers represent a potential paradigm shift in bioprocessing, according to Laura Chirica, CEO of Cellevate, adding that the microcarriers have up to 60x the surface area of “traditional” carriers, creating a three-dimensional cell culture environment, significantly increasing viable cell densities and viral vector yields in stirred tank reactors. Cellevate plans to launch the nanofiber microcarriers at BIO-Europe in Stockholm.
“Scaling up at Testa Center in a 10-L stirred tank bioreactor with our new category of nanofiber-based cell culture systems, while maintaining all the cell culture parameters unchanged from lab scale, is a great achievement. The study also demonstrated the ease of use and ease of implementation in bioreactors, and our ability to meet industrial bioprocessing scaleup demand,” she added.
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