In the rapidly developing field of spatial biology, researchers are working to expand our understanding of biological processes within their spatial context. Scientists are taking a holistic approach to achieve this goal, looking at how molecules, such as proteins or RNA, are organized and interact within tissues. This in-depth research will help provide deep insights into complex disease mechanisms, drug responses, and the development of personalized medicine.
In recent years, we have witnessed a breakthrough in spatial biology merging classic methods like immunohistochemistry with high throughput techniques like transcriptomics and proteomics. While RNA analysis is well-established, high-plex proteomics is emerging quickly. This is important, as proteins drive biological processes and offer tissue architecture insights missing in RNA data. Examples include:
- Understanding how cancer cells interact with their surroundings
- Studying how the immune system functions in different tissues
- Developing new drugs that target specific cell types and interactions
Until recently, spatial biology relied on single omics approaches, like transcriptomics or high-plex proteomics. New platforms enable multiomics analysis, ranging from high-plex transcriptomics with limited proteins to high-plex protein panels with focused RNA. These advancements have the potential to revolutionize both scientific research and clinical practice.
The future of spatial biology might lie in combining both techniques, giving researchers the ability to gain a comprehensive picture of gene and protein expression within a tissue section, providing the most detailed understanding of the cellular processes.
But it doesn’t stop there. Other modalities, such as light sheet microscopy, are a part of the spatial biology landscape and allow us to explore complex 3D samples, including whole mouse models, in stunning detail. Whether you’re deciphering your sample’s intricate 3D architecture, studying the complex interplay of proteins and RNA, or combining both approaches, Miltenyi Biotec offers complete workflow solutions from reliable reagents to innovative instrumentation and software.
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