Panelists:
Amanda Linkous, PhD
Research Associate Professor
Department of Pharmacology
Vanderbilt University
Panelist
Amanda Linkous, PhD
Amanda Linkous is a research associate professor in the department of pharmacology at Vanderbilt University. Her laboratory focuses on the development of 3D organoid models for recalcitrant primary and metastatic tumors.
Hannah Nicholson
Graduate Research Assistant
Precision One Health Initiative
College of Veterinary Medicine
University of Georgia
Panelist
Hannah Nicholson
Hannah Nicholson holds a BS in Chemistry and a BSA in Biological Science and is currently pursuing a PhD in comparative biomedical sciences at the University of Georgia. She is a member of the SMART Translational Medicine Lab, under the advisement of Jonathan Mochel, PhD. Her work centers on the development of canine and feline adult stem cell-derived kidney organoids for the study of chronic kidney disease, with additional interests in establishing avian organoids to investigate viruses affecting poultry.
Ben Josey, PhD
Senior Field Application Scientist
Corning Life Sciences
Panelist
Ben Josey, PhD
Ben Josey is a senior field application scientist at Corning Life Sciences. He received his doctorate from the Medical University of South Carolina and has worked broadly in the fields of biomaterials, stem cells, immune cells, viruses, and biobank management. Since joining Corning, he has worked extensively with academic and industry researchers, process development teams, and manufacturing groups, optimizing assays and scale-up conditions for virus production and cellular therapeutics. In addition to this, he also works with various academic, industry, and government agencies to improve sustainability and workforce development challenges faced by the biopharma industry.
- Time:
Traditional cell cultures and animal models fail to fully capture the cellular diversity, tissue architecture, and signaling networks that drive disease progression and therapeutic resistance. That’s why three-dimensional (3D) platforms like organoids, which can accurately recreate the cellular heterogeneity and microenvironmental context of native tissues, are becoming increasingly important in the context of oncology, infectious disease, and other research areas.
In this GEN webinar, two experts in the field will highlight the powerful potential of organoid platforms to unearth hidden details of complex disease mechanisms. Amanda Linkous, PhD, will describe how her team created 3D organoid models of the human lung and brain that helped them capture tumor-tumor and host-tumor interactions that underlie brain metastasis in patients with lung cancer. Hannah Nicholson will describe how her group developed the first chicken lung organoids derived from adult chicken stem cells. These organoids provide a physiologically relevant 3D model for studying how avian influenza viruses evolve and interact with their hosts.
Webinar attendees will learn:
- How organoid systems can reveal fundamental tumor–host and virus–host interactions that are often obscured in traditional models.
- How organoids effectively capture the cellular heterogeneity and microenvironmental context underlying tumor progression and viral adaptation.
- Approaches for using organoids to investigate the mechanisms of lung cancer metastasis to the brain.
- Insights from chicken lung organoids on viral entry, replication, and the evolutionary potential of high-pathogenicity viral strains.
A live Q&A session will follow the presentations, offering you a chance to pose questions to our expert panelists.
Produced with support from:
The post Modeling Complex Cancer and Viral Infection Mechanisms with Advanced Organoid Platforms appeared first on GEN – Genetic Engineering and Biotechnology News.
