Gene Signature for High-Risk Form of Acute Lymphoblastic Leukemia Identified by CHOP Scientists
Scientists from the Children’s Hospital of Philadelphia (CHOP) report that they have discovered the underlying biology that identifies a subset of patients with acute lymphoblastic leukemia who have a higher risk version of the...
Bitter Taste Receptor Engages Compounds Not Just Outside the Cell, but Inside
A bitter taste receptor, TAS2R14, has been shown to respond to both extracellular and intracellular signals. Indeed, it can respond to both signals simultaneously. This finding is especially interesting because bitter taste receptors are...
Researchers develop new approach to effectively deliver therapeutics into the brain
Researchers at the Icahn School of Medicine at Mount Sinai have developed an innovative approach-;demonstrated in mouse models and isolated human brain tissue-;to safely and effectively deliver therapeutics into the brain, providing new possibilities...
Xiaorong He on Boehringer Ingelheim’s Investments in AI, Broader Applications in Pharma
At the 2024 BioFuture conference held in October in New York City, GEN sat down with Xiaorong He, PhD, Senior Vice President, Site Head Development U.S. and Head of Global Development Sciences, Boehringer Ingelheim...
UChicago scientists develop a new approach to study snoRNAs
Dynamic, reversible modifications of DNA and RNA regulate how genes are expressed and transcribed, which can influence cellular processes, disease development, and overall organismal health. Small nucleolar RNAs (snoRNAs) are a common but overlooked...
AI-designed drug ISM5939 granted IND clearance for cancer clinical trials
Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announced that it has received IND clearance from FDA for ISM5939, a potential best-in-class oral small molecule inhibitor targeting ENPP1 for the...
Nanomedicine using gas bubbles offers hope for lung cancer treatment
The delivery of nanomedicines using gas bubbles has shown itself to be a unique way of transporting cytotoxins to the lungs of cancer patients. The method enables precise and focused treatments, and the local...
Repair Proteins Collaborate in “Hubs” to Repair DNA Damage
DNA can be damaged by normal cellular processes as well as external factors such as UV radiation and chemicals. Such damage can lead to breaks in the DNA strand. If DNA damage is not...
Thermo Fisher’s Accelerator Expands CRO, CDMO Services
More than three years after acquiring the clinical research organization (CRO) PPD, and seven years after expanding into the contract development and manufacturing organization (CDMO) market by purchasing Patheon, Thermo Fisher Scientific has launched...
ProductLife Group (PLG) Acquires Halloran
BOSTON; Oct. 16, 2024 (Business Wire) – ProductLife Group (PLG), a trusted global leader in regulatory, scientific, compliance, and digital transformation consulting services for the life sciences, today announced the acquisition of Halloran Consulting Group, a life...
