Bacterial Antiviral Mechanism Triggers Growth Arrest through de novo Neo Gene
Because CRISPR news tends to focus on the applications of genome editing—such as treating genetic diseases or improving food—it may be easy to forget that the system is, at its core, used by bacteria...
New insights into topoisomerase I inhibition reveal potential pathways for cancer therapies
A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I, a protein crucial for many biological processes...
Insilico Medicine’s pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment
Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced ISM6331, potential best-in-class pan-TEAD inhibitor, has received the U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) clearance for the...
Achieving quantum memory in the hard X-ray range
Light is an excellent carrier of information used not only for classical communication technologies but also increasingly for quantum applications such as quantum networking and computing. However, processing light signals is far more complex,...
Flu Vaccine Strategy Pairs Injection and Nasal Spray, Shows Promise in Pigs
In a study headed by researchers at the Institute of Virology and Immunology (IVI) in Mittelhäusern, a new, two-step flu vaccination strategy that pairs intramuscular injection of a viral vectored flu vaccine with nasal spray...
Protein Production Pattern Can Predict Melanoma Therapy Severe Side Effects
Scientists at NYU Langone Health, its Perlmutter Cancer Center, and collaborators report that an activity pattern in certain genes responsible for building spleen tyrosine kinases can predict which melanoma patients are likely to have...
Alzheimer’s Treatment Improved by Light-Activated Exosome Protein Delivery
Delivery of therapeutic proteins or other intracellular materials has been a long-standing challenge for translational medical researchers. Effective strategies can present a powerful tool for many treatment strategies including CRISPR or small molecule delivery.
In...
Steady flight of kestrels could help aerial safety soar
A new joint study by RMIT and the University of Bristol has revealed secrets to the remarkably steady flight of kestrels and could inform future drone designs and flight control strategies.
Credit: RMIT
A new joint...
Discovery of Tr1 cells as a barrier to cancer immunotherapy offers new hope for...
Immunobiologists Robert Schreiber, PhD, (left) and Hussein Sultan, PhD, of Washington University School of Medicine in St. Louis, found that a subset of immune cells that normally puts the brakes on the immune system...
Researchers uncover immune system barrier to cancer treatment
By recruiting the immune system to combat tumor cells, immunotherapy has improved survival rates, offering hope to millions of cancer patients. However, only about one in five people responds favorably to these treatments. With...
