Precision pulmonary medicine: Penn engineers target lung disease with lipid nanoparticles
Penn Engineers have developed a new means of targeting the lungs with lipid nanoparticles (LNPs), the miniscule capsules used by the Moderna and Pfizer-BioNTech COVID-19 vaccines to deliver mRNA, opening the door to novel...
Protein-Protein Interactions Dance into the Spotlight
In an intricate dance, missteps or errant gestures between two partners can disturb the entire ensemble. Such is the molecular dance that is life. Here, the partners that need to hit their cues, execute...
Bioconjugates Meet and Promise to Exceed Expectations
One of the fastest-growing segments of pharmaceuticals, as highlighted at the 2024 J.P. Morgan Healthcare Conference, is the antibody-drug conjugate (ADC) segment. ADCs consist of four main elements: a monoclonal antibody (mAb) designed to...
Investigating cell killers: Advanced system for size-dependent cytotoxicity analysis of silica
Metal nanomaterials have become an indispensable part of industrial and medical fields due to their unique and versatile properties. Their size, which imparts them with the desired physiochemical properties, is also the reason for...
Form Bio’s AI Ensures Gene Therapies Pass Muster, with Ginkgo’s Help
The cell and gene therapy field is, some say, at a tipping point—poised to take off. The FDA has noted that, by next year, they aim to approve 10–20 new cell and gene therapies...
Novel brain organoid model unveils link between inflammation and astrocyte dysfunction
The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain. The other half-;roughly 85 billion cells-;are non-neuronal cells called...
Shedding light on the intricacies of numerical simulations of soil behavior
A solid understanding of soil mechanics and behavior is one of the fundamental pillars of geotechnical engineering. The stability and resilience of many modern geotechnical structures, including building foundations, dams, bridges, and embankments, rely...
Redefining Cell and Gene Therapy Navigation
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Making the right choices in manufacturing and testing early-on is critical for gaining regulatory approval and achieving patient access faster. Charles River’s suite of cell and gene therapy solutions can support your drug’s...
FB1006: AI-discovered drug advances to clinical trials for ALS treatment
Amyotrophic Lateral Sclerosis (ALS) is a fatal type of motor neuron disease characterized by progressive degeneration of nerve cells in the spinal cord and brain, resulting in muscle weakness and paralysis that can include...
Down Syndrome Memory and Learning Deficits Linked to Long Noncoding RNA
A study in mouse models and human tissue, carried out by researchers at the Barcelona Institute of Science and Technology Centre for Genomic Regulation (CRG), has found that the small nuceleolar RNA host gene,...
