Cancer Drug Shortfalls Tied to How BET Inhibitors Hit BRD2 and BRD4 Differently
For more than a decade, BET inhibitors have been touted as one of cancer therapy’s most promising drug classes. The logic was straightforward: many tumors rely on oncogenes that depend on BET (bromo- and...
Seer to Apply Deep Proteomics Tech to Singapore Population Cohort Study
This week, Seer, a developer of proteomics technology, said that scientists involved in the PRECISE-SG100K initiative will use the company’s Proteograph® product suite to profile the plasma proteome of about 10,000 participants. The data...
UVA scientists develop AI tools to accelerate new drug discovery
University of Virginia School of Medicine scientists have developed a bold new approach to drug development and discovery that could dramatically accelerate the creation of new medicines. UVA's Nikolay V. Dokholyan, PhD, and colleagues...
Neuroblastoma Tumor Growth in Mice Suppressed by Blocking Enzyme to Inhibit mTOR Signaling
Neuroblastoma is the most common tumor among children under a year of age, and while in its gentlest form neuroblastoma can regress on its own, it can also take an aggressive form, with high-risk...
Neurocrine Grows in Endocrinology, Rare Disease with $2.9B Soleno Buyout
Neurocrine Biosciences has agreed to acquire Soleno Therapeutics for $2.9 billion, the companies said, in a deal designed to bolster the buyer’s portfolio of marketed endocrinology and rare disease therapies.
“This transaction will advance Neurocrine’s...
OYE Therapeutics doses first subject in bridging study of intravenous caffeine formulation
OYE Therapeutics Inc., a clinical-stage biotechnology company developing therapies for perioperative and emergency medicine, announced that the first subject has been dosed in its scientific bridging study evaluating OYE-101. The novel intravenous caffeine formulation...
Base editing corrects genetic mutation responsible for severe form of inherited epilepsy
University of Virginia School of Medicine scientists have used a next-generation form of gene editing to fix the underlying cause of a severe form of epilepsy in lab mice. Their promising results suggest the...
Microplastics in Human Bile Drive Mitochondrial Dysfunction and Senescence
Microplastics have become a defining environmental signature of modern life, turning up in oceans, soil, food, drinking water, and even the air. But their biological fate inside the human body remains far less understood....
Nanotube Injector Boosts Mitochondrial Performance Through Cytoplasmic Transfer
Extracting cytoplasmic material such as proteins, RNA, and mitochondria often relies on cell lysis using detergents or enzymes, which destroy the cells. Ultrasound and other sophisticated physical disruption methods need to be carefully tuned...
Organ-on-chip model advances study of sexually transmitted infections
Sexually transmitted infections (STIs) not only impact an individual's health but also result in multibillion-dollar economic losses worldwide. To study these diseases, a team of researchers has developed the first-of-its-kind immune-capable "organ-on-a-chip" model that...
