StockWatch: Abivax Shares Leap on Phase III Ulcerative Colitis Data, $747.5M Offering
Abivax CEO Marc de Garidel
A day after surpassing its own expectations with dazzling Phase III data for its lead pipeline candidate, the oral ulcerative colitis (UC) drug obefazimod, Abivax (Euronext Paris and NASDAQ: ABVX)...
New model predicts mRNA protein production, accelerating drug and vaccine discovery
A new artificial intelligence model can improve the process of drug and vaccine discovery by predicting how efficiently specific mRNA sequences will produce proteins, both generally and in various cell types. The new advance,...
Protein Core Stability Rules Open Door for Faster Protein Design
It has long been thought that protein function and stability are highly sensitive to changes in the composition of the internal structures, or protein cores. However, a large-scale experiment probing the inner architecture of...
AI-Designed Proteins Enable Scalable Precision Immunotherapy
Within each individual’s immune system is a unique repertoire of billions of T cells patrolling the body to uncover and eliminate foreign threats. Yet this army is not foolproof and can miss the subtle...
IRF-5 identified as key to preventing immune cell exhaustion
In fighting chronic infections or certain cancers, CD8+ T cells-the immune system's frontline soldiers-eventually become exhausted. They lose effectiveness and respond less efficiently to threats. This weakening is a major therapeutic challenge, as it...
After Layoffs, Korro Bio Retains “3-2-1” Vision as It Prepares for Liftoff
Ram Aiyar, PhD, Korro Bio CEO and president
Two months after laying off 20% of its staff, Korro Bio says it has not retreated from its ambitious slogan, “Edit the message. Rewrite the future,” or...
Biological Clock Temperature Cycles Explained by Waveform Distortion
Most biochemical reactions accelerate as temperature increases, but our daily circadian rhythms, which are underlain by gene regulatory and biochemical networks, remain constant, even as temperatures rise. Researchers led by Gen Kurosawa, PhD, at...
Low-cost diagnostic tool delivers COVID-19 test results in under an hour
An affordable new diagnostic tool that delivers COVID-19 test results in under an hour could help boost pandemic preparedness in resource-poor regions, according to a team of researchers. The reverse transcription loop-mediated isothermal amplification...
Jura Bio’s AI Data Loop Enables Large-Scale De Novo Antibody Design
“High quality, large-scale, fit-for-purpose datasets” continues to be the tagline for artificial intelligence (AI) models aiming to achieve scalable drug discovery to novel targets. While troves of public datasets from the Protein Data Bank...
Probiotic strains have different effects on gut recovery after antibiotics
All probiotics are not created equal, according to new research from North Carolina State University. In a mouse model, researchers found that different probiotic strains can either accelerate or delay the gut microbiome's recovery...
