1910 Unlocks Macrocyclic Peptide Drugs Using PEGASUS AI Model
1910 is on a mission to “make undruggable targets a thing of the past” by “turning every pharma company into an AI company,” says founder and CEO, Jen Asher, PhD. The Sam Altman–backed AI drug...
New exercise-sensing pathway offers hope for osteoporosis treatment
A research team from the Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine at the University of Hong Kong (HKUMed) has uncovered a key biological mechanism that explains how exercise maintain...
Vitamin A derivative suppresses immune response and cancer vaccine efficacy
Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by which a metabolic derivative of vitamin A-all-trans retinoic acid-compromises both the body's normal anti-cancer immune response...
CHANGE-seq-BE Developed to Allow Scientists to Better Understand Base Editors
Scientists at St. Jude Children’s Research Hospital report that they have developed an unbiased, sensitive, and resource-efficient method to identify small, off-target sites that pose a safety risk when using CRISPR gene editing technology....
StockWatch: Ultragenyx, Mereo Plummet on Brittle Bone Candidate Failures
Ultragenyx Pharmaceutical (NASDAQ: RARE) and Mereo BioPharma Group (NASDAQ: MREO) may be wishing for a happy new year in 2026 after the companies ended 2025 by announcing bad news—namely, the failures of their brittle...
New method can help better assess precision genome editing technology
Scientists and physicians can better assess precision genome editing technology using a new method made public today by St. Jude Children's Research Hospital. Significant amounts of time and resources spent improving CRISPR gene editing...
First human ‘lung-on-chip’ model developed using stem cells from a single donor
Researchers at the Francis Crick Institute and AlveoliX have developed the first human 'lung-on-chip' model using stem cells taken from only one person. These chips simulate breathing motions and lung disease in an individual,...
Best Wishes to GEN Readers in 2026
Dear GEN Readers:
As we close 2025, I along with the entire GEN team want to wish all of you a happy, healthy, and successful new year. Thank you for your continuing interest in GEN’s...
Advancing stem cell regeneration through animal-free culture systems
Intestinal Stem Cells (ISCs) derived from a patient's own cells have garnered significant attention as a new alternative for treating intractable intestinal diseases due to their low risk of rejection. However, clinical application has...
SomaScan Surveying the Breadth and Depth of the Human Proteome
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By creating the first complete map of the human genome, the Human Genome Project made genetics an everyday topic that any well-informed person could comment on. Even so, the human genome is only...
