Blobby Bodies Help Cells Regulate the Cytoplasm’s Electrochemical Environment
In living cells, regulation of the electrochemical environment is supposed to be managed by ion channels—protein complexes that reside in cell membranes and assume definite shapes. So, it’s surprising to learn that the electrochemical...
ISM2196: A promising AI-developed WRN inhibitor for advanced metastatic cancers
Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced the nomination of ISM2196, an AI-driven, potential best-in-class small molecule WRN inhibitor targeting advanced metastatic microsatellite instability (MSI) cancers guided by synthetic...
Genetic Alphabet Expanded to Create New Proteins
Scientists trying to engineer biologic molecules with new functions have long felt limited by the 20 amino-acid building blocks. Researchers are working to develop ways of putting new building blocks—called non-canonical amino acids—into their...
Damaged DNA in Colorectal Cancer Chemo Patients Might Be Repaired More Effectively with New...
An international research team from the University of Oxford and Nanyang Technological University (NTU Singapore) reports the discovery of a new process for repairing damaged DNA that is particularly relevant for patients undergoing colorectal...
New discovery offers hope for overcoming CAR-T cell therapy resistance
Mayo Clinic researchers mined the molecular foundations of cancer and uncovered a new reason chimeric antigen receptor (CAR-T cell therapy) fails in some patients. This discovery has fueled new strategies that incorporate antibodies and gene editing to...
Expanding the Applications of Chromatographic Materials
Solventum, the recent healthcare spinoff of 3M, is expanding the range of applications for its fibrous chromatography material. The company hopes to offer the 3M Harvest RC Chromatographic Clarifier, launched in 2021, for chromatography...
Gene Therapy Is Developing Rapidly in the Asia Pacific
The Asia-Pacific gene therapy market was valued at $349.1 million in 2020 and is expected to grow at a compound annual growth rate (CAGR) of 36.8% to reach nearly $7 billion in 2030. This...
Scripps Research develops breakthrough technique for adding unique amino acids to proteins
It's a dogma taught in every introductory biology class: Proteins are composed of combinations of 20 different amino acids, arranged into diverse sequences like words. But researchers trying to engineer biologic molecules with new...
IR-Based Cell Imaging System Filters Out Water’s Effects, Focuses on Biomolecules
If you were to use infrared (IR) transmission microscopy, you would appreciate its chemical quantification abilities—unless your object of study was a hydrated cell. In that case, you might complain about being reduced to...
New normative neuroimaging library sets standard for brain injury research
With recent advances in neuroimaging, moving from qualitative to quantitative outputs, an understanding is needed of what normal data look like to be able to apply these advances to diagnosis and outcomes prediction in...
