Small-Molecule “Unsilencers” Show Promise against Angelman Syndrome
Angelman syndrome (AS) is a rare genetic disorder characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities. There is no cure for the disorder, named after Harry Angelman, MD—who first reported the...
Characterizing AAV Charge Heterogeneity Using High-Resolution icIEF Fractionation with LC-MS Analysis
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Broadcast Date: Saturday, June 22, 2024Time: 9:00 am PT, 12:00 pm ET, 18:00 CEST
Adeno-associated viral (AAV) gene therapy products, which contain a DNA transgene packaged into a protein capsid, have...
Advancing genomics research: An inside look at Azenta Life Sciences’ new Oxford Genomics Laboratory
insights from industryDavid Buck, Director of Operations, Azenta Life SciencesJohn Todd, Professor of Precision Medicine, University of Oxford This interview delves into the capabilities and services of Azenta Life Sciences' new Oxford Genomics...
Machine learning identifies cancer-driving mutations at CTCF binding sites
In a recent study published in the journal Nucleic Acids Research, researchers investigate whether machine learning can identify pan-cancer mutational hotspots at persistent CCCTC-binding factor (P-CTCF) binding sites (P-CTCFBSs). Study: Machine learning enables pan-cancer...
Migrating starlings are no copycats
Young, naïve starlings are looking for their wintering grounds independently of experienced conspecifics. Starlings are highly social birds throughout the year, but this does not mean that they copy the migration route from each...
Scientists create first mouse model with complete, functional human immune system
A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling. Scientists at The University of Texas Health Science Center at San Antonio have created a humanized mouse model with a human...
Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment
Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, has successfully delivered the second preclinical candidate compound (PCC) in its collaboration with Fosun Pharma in June 2024, a potential innovative therapeutic using...
Exploring the radiative effects of precipitation on arctic amplification and energy budget
One of the key metrics for climate modelling is radiative forcing. Most climate models, including the general circulation models (GCMs), focus on the effects of different atmospheric factors on radiative forcing. However, there are...
Exploring PRM-A as a novel glycan-targeted therapy for SARS-CoV-2 inhibition
HIV, Ebola and most recently, COVID-19 viruses have had an enormous impact on our societies world-wide. All these viruses are 'enveloped viruses,' viruses that have an exterior envelope that surrounds them largely composed of...
Turning cancer cells against themselves to overcome drug resistance
Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind. But...
