Why AI Alone Isn’t Enough for Oligonucleotide Discovery
AI is reshaping drug discovery, and nucleic acid–based medicines, including mRNAs, gene therapy, and oligonucleotide therapeutics, are no exception. By optimizing sequences and chemical modifications for experimental testing, AI accelerates discovery timelines, which is...
Implantable cytokine factories show promise against advanced ovarian cancer
Implantable cytokine factories designed to deliver immunotherapy directly at the site of disease have taken an important step toward clinical reality. Researchers at Rice University, in collaboration with The University of Texas MD Anderson...
Scientists call for explainable AI in protein language models
Protein language models are artificial intelligence tools which help engineer proteins with useful properties, including completely new structures never seen before in nature. The technology has huge potential for addressing global challenges, such as...
Cholesterol Drug May Weaken Ovarian Cancer’s Metastatic Defense
The accumulation of fluid in the belly, known as ascites, is something that women with advanced ovarian cancer may know all too well. The results of research by a team at Duke University School...
Uncountable expands specialty chemicals footprint with four new deals
Uncountable, a software company that develops AI platforms for end-to-end product development, today announced it has signed four new agreements with specialty chemicals organizations to support formulation development, scale-up, and production optimization. The new...
StockWatch: enGene Shares Crater on Declines in Complete Response Rates to Bladder Cancer Therapy
enGene (NASDAQ: ENGN) stock suffered an 83% plunge this past week that reflects just how competitive the field is among drug candidates for nonmuscle invasive bladder cancer (NMIBC)—and how questions over clinical data are...
Diabetes Drug Metformin’s Blood Glucose-Lowering Effects Tied to Action on Gut Cells
For decades, physicians and scientists have thought that metformin, a biguanide drug that is prescribed for millions of people worldwide for type 2 diabetes (T2D), mainly targets the liver to suppress glucose production. A...
How Digital Orchestration Is Redefining Regulatory Infrastructure for Cell and Gene Therapy
The rapid growth of cell and gene therapies is exposing structural limitations in how traditional biopharmaceutical systems were designed. Unlike batch-based manufacturing models, these therapies are patient-specific, requiring tightly coordinated execution across clinical, manufacturing,...
ParcelBio Unveils Programmable mRNA Platform Backed by $13M Financing
Biotechnology company ParcelBio said this week that it has raised $13 million in a seed financing round led by Breyer Capital with participation from General Catalyst, Y Combinator, Metaplanet, SurgePoint Capital, ZAKA VC, and...
New ‘heart-on-a-chip’ to halt cardiac damage caused by Duchenne
Duchenne Parent Project Spain (DPPE) has launched the BEAT Project, a research initiative focused on one of the key challenges associated with Duchenne and Becker muscular dystrophies: progressive heart damage. Cardiomyopathy is the leading...
